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Inflammatory Musculoskeletal Disorders: Rheumatoid Arthritis

Description

Arthritis, Juvenile Rheumatoid : Rheumatoid arthritis of children occurring in three major subtypes defined by the symptoms present during the first six months following onset: systemic-onset (Still's Disease, Juvenile-Onset) polyarticular-onset, and pauciarticular-onset. Adult-onset cases of Still's disease (STILL'S DISEASE, ADULT-ONSET) are also known. Only one subtype of juvenile rheumatoid arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent. [1]

Tumor Necrosis Factor : Serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes which has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. It mimics the action of endotoxin but differs from it. It has a molecular weight of less than 70,000 kDa. [1]

[1] MeSH 2001 © National Library of Medicine


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  http://www.hon.ch/Dossier/MotherChild/child_musculoskeletal/muscoskel_arthritis.html Last modified: Jun 25 2002