Corticosteroids are a group of drugs similar to the natural
corticosteroid produced by the cortex of the
. Among the
disorders that often improve with corticosteroid treatment are , allergic
, and rheumatoid arthritis.
How these anti-inflammatory agents inhibit late phase allergic
reactions occurs via a variety of mechanisms, including decreasing the density of
along mucosal surfaces, decreasing chemotaxis and activation of ,
decreasing production by ,
, mast cells and eosinophils,
inhibiting the metabolism of and other mechanisms.
But for the side effects, corticosteroids would be the only drug needed for
treating most allergic reactions. Much effort is underway to develop safer corticosteroids
including topical application and modifying the molecules to preserve the
anti-inflammatory properties while minimizing the undesirable side effects.
Anti-Inflammatory Glucocorticoid, Inhaled Glucocorticoid, Oral Glucocorticoid
are , and catabolic to skin tissue. Long-term use has inhibitory effects on DNA
synthesis and cell division, which is considered to be causal to the side effects.
Many people suffer the symptoms of Cushing's syndrome because they take
glucocorticoid hormones such as prednisone for asthma, rheumatoid arthritis,
or other inflammatory diseases.
Any of the group of C21 corticosteroids, principally
aldosterone , which are predominantly involved in the regulation of electrolyte and water-balance through
their effect on ion transport in epithelial cells of the renal tubules. This results in
retention of sodium and loss of potassium. Some also possess varying degrees of
glucocorticoidactivity. Their secretion is regulated principally by plasma volume,
serum potassium concentration and angiotensin II and to a lesser extent by anterior